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Physiological Signal Dataset Development for AI/ML Wearable Device Research

AgencyHEALTH AND HUMAN SERVICES, DEPARTMENT OF

NAICS541715 · Research & Development in Engineering & Life Sciences

LSM990 Confocal Airyscan2 System

This notice is to update FAR clauses and the attachment. There are no other changes to this notice. 1 GENERAL INFORMATION This is a combined synopsis/solicitation for commercial products prepared in accordance with the Far Part 12 as supplemented with additional information included in this notice, and in conjunction Far 8.402(f). This announcement constitutes the only solicitation; quotations are being requested, and a separate written solicitation will not be issued. The National Institutes of Health (NIH), National Institute on Deafness and Other Communication Disorders (NIDCD), Intends to contract on a sole source basis with Carl Zeiss Microscopy – One North Broadway, White Plains, NY 10601 to procure a LSM 990 w/Airyscan-2 Microscope consisting of all the items per the attachment provided in this notice. The Government intends to award a Firm-Fixed-Price Purchase Order resulting from this solicitation. 2. DESCRIPTION OF REQUIREMENT 2.1 Background The NIDCD relies on high-resolution microscopy to image mouse inner ear tissues and to perform live imaging of cellular organelle development and function in zebrafish. The LSM990, equipped with the proprietary Airyscan 2 detector, provides the spatial resolution and sensitivity required to visualize subcellular structures that cannot be adequately resolved with conventional confocal microscopy. The 32-channel GaAsP detector array achieves resolution of approximately 90 nm in the lateral dimension and 200 nm in the axial dimension while simultaneously improving signal collection efficiency. The enhanced sensitivity of the Airyscan 2 detector allows imaging at lower laser powers, reducing photobleaching and phototoxicity during long-term live imaging experiments. This combination of high resolution and gentle imaging is essential for studying dynamic cellular processes in living tissues. In addition, the LSM990 offers substantial improvements in data handling compared with the older LSM780, generating raw datasets that are approximately eight-fold smaller and enabling Airyscan image processing that is up to five-fold faster. These advances improve both experimental throughput and data management for high-resolution live imaging studies. The Zeiss LSM 990 with Airyscan 2 enables gentle, high-sensitivity imaging of both live and fixed samples, including fine structures in the mouse inner ear and zebrafish lateral line. The Airyscan 2 detector array improves signal detection and spatial resolution while allowing imaging at low laser power, thereby minimizing photobleaching and phototoxicity. The Labs’ current Zeiss LSM780 confocal system is heavily used by researchers from three NIDCD laboratories and is no longer covered by a service contract, with many replacement parts no longer available. Zeiss ZEN software is user-friendly and intuitive, allowing new users to become proficient quickly. Because the LSM990 operates on the latest version of the same software platform, it will provide a seamless transition while ensuring reliable, faster, higher-quality, and more efficient image acquisition for the many NIDCD investigators who depend on this system. Overall, the Zeiss LSM 990 will provide essential imaging capabilities and meet current and future microscopy needs at NIDCD. Brand Name Only: Sole Source Authority - 12.102(b) for Open Market and 8.405-6 for GSA items The Airyscan detector of LSM990 system represents a proprietary technology from Carl Zeiss Microscopy, LLC and a continuation of Airyscan detector use in the lab is essential to generate high-resolution publication quality data and efficiently complete the research projects that are ongoing in the lab using this detector, only Zeiss LSM990 system would suffice the goal. 3. DELIVERY / PLACE OF PERFORMANCE Delivery, installation, re-alignment and recalibration once the microscope systems have been added to its permanent location in the lab. National Institutes of Health 9000 Rockville Pike Building 35A, Room 1D-9…

AgencyHEALTH AND HUMAN SERVICES, DEPARTMENT OF

NAICS334516

PlaceBethesda, MD

Brain Repair of Any Injured Neural Structure (BRAINS)

AgencyHEALTH AND HUMAN SERVICES, DEPARTMENT OF

NAICS541715 · Research & Development in Engineering & Life Sciences

PlaceWashington, DC

Hearing Enhancement through ARtificially Intelligent NeurotechnoloGy (HEARING)

AgencyHEALTH AND HUMAN SERVICES, DEPARTMENT OF

NAICS541715 · Research & Development in Engineering & Life Sciences

PlaceWashington, DC

Notice of Intent: Storage and distribution services for 438.75 cu ft of paper research and pathology reports; and 1,670.12 cu ft of pathology paraffin embedded tissue blocks and tissue fixed slides used in the Laboratory of Pathology, CCR, NCI.

THIS IS A NOTICE OF INTENT AND NOT A REQUEST FOR QUOTATIONS. This notice is published in accordance with Federal Acquisition Regulation (FAR) 5.101(a)(1) requiring the dissemination of information regarding proposed contract actions. This is a Notice of Intent to award a sole source, firm-fixed price purchase order under the authority of 41 U.S.C. 3304(a)(1), as implemented by FAR 12.102 and 6.302-1 - Only One Responsible Source and No Other Supplies or Service Will Satisfy Agency Requirements and is not a request for competitive proposals. POP: 08/01/2026 to 07/31/2027 Option 1: Aug. 2027 – July. 2028 Option 2: Aug. 2028 – July. 2029 Option 3: Aug. 2029 – July. 2030 Option 4: Aug. 2030 – July. 2031 The National Institute of Health (NIH) Laboratory of Pathology intend to negotiate on a sole source basis with EPL Archives LLC on an other than full and open competition basis. The Laboratory of Pathology provides diagnostic services for the Clinical Center at the National Institutes of Health. The department provides pathological diagnosis of specimens submitted incidental to standard care and clinical investigation of National Institutes of Health patients and submitted by outside health organizations. As a result of our clinical and research missions, pathology blocks, slides, images, and hardcopy patient reports must be stored and available indefinitely. LP must continue to store a certain portion of these patient materials offsite due to space limitations in building 10. LP currently archives 438.75 cubic feet (351 boxes) of research documents and clinical patient records; 1,670.12 cubic feet of paraffin embedded pathology tissue blocks, and stained slides dating back to the 1980’s that are still requested for recruits and reviewed by clinical and research staff. EPL Archives facilities are environmentally controlled and protected against hazards, and the company provides GLP-compliant archive services and is the only storage facility we’ve utilized for archiving and all our materials are presently located there. LP has now been relocated as of July 2015; the onsite high-density storage facility has been renovated but is inadequate space for what has been stored offsite to remedy the storage problem. It would be beneficial to keep the materials where they’re stored now unless there’s a newer facility closer to the NIH Campus to make it cost effective to move all the materials. As archived material is needed, EPL provides a one-day turnaround to provide us with our necessary reports or slides, which ensures adequate turnaround times for LP’s services provided to our NIH researchers and clinicians. In addition, LP’s material has been stored at EPL for over a decade, and it would be unfeasible to move to another facility due to the potential cost it would take to package, inventory, and transport to another facility, but we understand to find out, it must be advertised. Justification: 1. All Contractor employees who handle Material(s) shall be trained in cGMP regulations and in the specific standard operating procedures for their activities. All Contractor employees who maintain government’s Material(s) shall be trained and acknowledge compliance with the HIPAA and Privacy Act. Contractor shall provide evidence that personnel are qualified to handle the government’s Material(s) and have been trained and acknowledge compliance with adherence to the laws that govern patient privacy. Contractor will maintain written records (inventory and transaction records) on each Deposit Materials consisting of correspondence between Contractor and the Depositor, information provided by Depositor on the type of material included in the Deposit Material and designation of Depositor’s ownership of the Deposit Materials. Depositor may review these records with respect to the Deposit materials, with the exception of locator codes, and copies may be obtained, or originals …

AgencyHEALTH AND HUMAN SERVICES, DEPARTMENT OF

NAICS561990

PlaceSterling, VA

BRAND NAME AGILENT OPENLAB CDS AND ECM SOFTWARE MAINTENANCE

The Office of Pharmaceutical Quality Research (OPQR) is a CDER laboratory-based office that utilizes broad range of analytical methods and computer modeling to conduct research to evaluate the product and process design their impact on product quality. The Agilent OpenLab CDS (Chromatography Data System) and ECM (Enterprise Content Management) system currently in use at the Office of Pharmaceutical Quality Research (OPQR) needs a service contract to ensure that software is updated, and all reported problems are properly addressed. Agilent OpenLab CDS and ECM system is used on a daily basis in conjunction with various research and regulatory studies performed at OPQR. It is the principal software used to control HPLC systems and to analyze and save chromatographic data. Therefore, it is critical to the Office’s mission.

AgencyHEALTH AND HUMAN SERVICES, DEPARTMENT OF

NAICS334516

Place0, MD

Clinical Trial Management System for TB Clinical Research

AgencyHEALTH AND HUMAN SERVICES, DEPARTMENT OF

NAICS54151

PlaceAtlanta, GA